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Aspergillus Spondylodiscitis in an Immunocompetent Patient With Recurrent Aspergillus Endocarditis; A Clinical Case

Mohsen Meidani1, Maryam Moradi2, Mehrzad Rahmanian3

  • 1Department of Infectious Diseases, School of Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

Open Forum Infectious Diseases
|April 21, 2025
PubMed
Abstract

Insights

This case highlights recurrent aortic valve Aspergillus endocarditis in an immunocompetent patient. Early recognition and treatment with antifungal agents are crucial for managing this rare but severe fungal infection.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Mycology

Background:

  • Fungal endocarditis, particularly Aspergillus endocarditis, is a rare but life-threatening condition.
  • It frequently affects prosthetic valves, especially the aortic valve, and can occur even in immunocompetent individuals.

Purpose of the Study:

  • To report a case of recurrent aortic-valve Aspergillus endocarditis in an immunocompetent patient.
  • To emphasize the importance of early diagnosis and treatment in both immunocompromised and immunocompetent hosts.

Main Methods:

  • Case report detailing a patient with recurrent aortic-valve Aspergillus endocarditis.
  • Description of clinical presentation, diagnostic findings, and treatment response.

Main Results:

  • The patient, a Caucasian male without prior immunocompromised status, presented with recurrent aortic-valve Aspergillus endocarditis.
  • The case involved multiple brain septic emboli and spondylodiscitis.
  • The patient showed a successful response to liposomal amphotericin B therapy.

Conclusions:

  • Aspergillus endocarditis requires consideration in patients with prosthetic valves and culture-negative endocarditis.
  • Prompt diagnosis and combined surgical and antifungal treatment are essential for favorable outcomes.
  • Vigilance is necessary for both immunocompromised and immunocompetent individuals.
Keywords:
Aspergillus endocarditisendocarditisimmunocompetencyrecurrent aspergillusspondylodiscitis

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