RNA secondary structure prediction by conducting multi-class classifications

Generating valid predictions of RNA secondary structures is challenging. Several deep learning methods have been developed for predicting RNA secondary structures. However, they commonly adopt post-processing steps to adjust the model output to produce valid predictions, which are complicated and could limit the performance. In this study, we propose a simple method by considering RNA secondary structure prediction as multiple multi-class classifications, which eliminates the need for those complicated post-processing steps. Then, we use this method to train and evaluate our model based on the attention mechanism and the convolutional neural network. Besides, we introduce two additional methods, including data augmentation to further improve the within-RNA-family performance and a method to alleviate the performance drop in the cross-RNA-family evaluation. In summary, we could produce valid predictions and achieve better performance without complex post-processing steps, and we show our additional methods are beneficial to the performance in within-RNA-family and cross-RNA-family evaluations.