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Enantioselective Crystallization on Chiral Hybrid Magnetic Polymeric Particles
Yarden Ben Moshe1,2, Meir Abuaf1,2, Chen Mordechai3,2
1Department of Chemistry, Bar-Ilan University, Ramat Gan 5900002, Israel.
Abstract:
A new class of Janus chiral magnetic polymeric particles was fabricated for chiral resolution by enantioselective crystallization. N-Acryloyl-l/d-Phe methyl ester beads were prepared with controlled sizes and coated with ferromagnetic permalloy. Chiral discrimination by enantiopure d-Ala crystals was investigated in a model for racemic crystallization. X-ray diffraction and differential scanning calorimetry support the crystallization of the particles. Analysis of optical rotation reveals a d-Ala enantiomeric excess of about 11%, effectively establishing the concept of chiral discrimination by enantioselective crystallization on these Janus chiral magnetic polymeric particles.
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