Electrochemically Active Materials for Tissue-Interfaced Soft Biochemical Sensing

Tissue-interfaced soft biochemical sensing represents a crucial approach to personalized healthcare by employing electrochemically active materials to monitor biochemical signals at the tissue interface in real time, either noninvasively or through implantation. These soft biochemical sensors can be integrated with various biological tissues, such as neural, gastrointestinal, ocular, cardiac, skin, muscle, and bone, adapting to their unique mechanical and biochemical environments. Sensors employing materials like conductive polymers, composites, metals, metal oxides, and carbon-based nanomaterials have demonstrated capabilities in applications, such as continuous glucose monitoring, neural activity mapping, and real-time metabolite detection, enhancing diagnostics and treatment monitoring across a range of medical fields. Next-generation tissue-interfaced biosensors that enable multimodal and multiplexed measurement of biochemical markers and physiological parameters could be transformative for personalized medicine, allowing for high-resolution, time-resolved historical monitoring of an individual's health status. In this review, we summarize current trends in the field to provide insights into the challenges and future trajectory of tissue-interfaced soft biochemical sensors, highlighting their potential to revolutionize personalized medicine and improve patient outcomes.