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HLA-B51 Positivity Correlates With Symptom Completeness From Recurrent Aphthous Stomatitis to Complete Behçet's
Bo Hyun Lee1, Kyung Bae Chung2, Hyunwoo Jang2
1Yonsei University College of Medicine, Seoul, Republic of Korea.
The Journal of Dermatology
|April 21, 2025
Summary
HLA-B51 positivity is linked to more severe Behçet's disease (BD) symptoms, particularly in males, influencing skin, ocular, and genital manifestations. This genetic factor impacts disease expression and severity.
Area of Science:
- Immunogenetics
- Rheumatology
- Clinical Medicine
Background:
- HLA-B51 is a known genetic risk factor for Behçet's disease (BD).
- Limited research exists on HLA-B51's role in the full spectrum of BD clinical presentation.
- Understanding genetic associations is crucial for disease management.
Purpose of the Study:
- To investigate the association between HLA-B51 status and the completeness of clinical manifestations in Behçet's disease.
- To analyze how HLA-B51 positivity correlates with specific symptoms and demographic factors in BD patients.
Main Methods:
- Retrospective review of 1203 patient medical records (June 2012-June 2017).
- Classification of 878 diagnosed BD patients into complete and incomplete disease groups based on revised Japanese criteria.
- Analysis of HLA-B51 status and clinical data, including demographics and symptom prevalence.
Main Results:
- 45.6% of BD patients were HLA-B51 positive, with increased positivity correlating with symptom severity.
- Male patients showed higher HLA-B51 positivity and more skin/ocular symptoms.
- Females had higher rates of erythema nodosum and genital ulcers; positive correlation between skin lesions and genital ulcers, negative with ocular symptoms.
Conclusions:
- HLA-B51 positivity significantly impacts the clinical phenotype of Behçet's disease.
- Genetic factors like HLA-B51 play a key role in disease expression, informing diagnostic and therapeutic strategies.
- Further research can refine understanding of genetic influences on BD symptomology.
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