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An Autonomously Liquefied Hydrogel Adhesive for Programmable Bioelectronic Interface
Mengyuan Li1, Gongwei Tian2, Xuemei Jiang1
1State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, 130012, P.R. China.
Angewandte Chemie (International Ed. in English)
|April 21, 2025
Summary
Researchers developed a new transient hydrogel adhesive for bioelectronics. This smart hydrogel offers programmable adhesion and autonomous detachment, simplifying device removal from hairy skin without damage.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Bioelectronics Engineering
Background:
- Hydrogel adhesives are crucial for drug delivery, regenerative medicine, and bioelectronics.
- Detachment of hydrogel adhesives under benign conditions is essential for surgical repair and implanted devices.
- Current stimuli-mediated detachment methods face challenges, especially for transient adhesives with programmable adhesion and autonomous detachment from substrates like hairy skin.
Purpose of the Study:
- To develop a transient hydrogel adhesive with programmable adhesion and autonomous detachment capabilities.
- To create a bioelectronic interface that ensures conformable and stable adhesion, even on hairy skin.
- To enable easy and damage-free removal of bioelectronic devices after use.
Main Methods:
- Utilized antagonistic enzyme reaction networks to drive the transient hydrogel adhesive.
- Investigated tunable mechanical properties and adjustable adhesive strength of the hydrogel.
- Demonstrated autonomous sol-gel-sol transition for programmable lifetime and detachment.
- Evaluated the hydrogel's adhesion to various materials, including hairy skin.
Main Results:
- The transient hydrogel adhesive exhibited tunable mechanical properties and adjustable adhesive strength.
- Achieved autonomous sol-gel-sol transition, enabling a programmable lifetime and detachment.
- Demonstrated conformable and stable adhesion to diverse materials, including hairy skin.
- Bioelectrodes coated with the hydrogel successfully recorded high-quality electromyogram, electrocardiogram, and electroencephalogram signals on hairy skin without hair shaving.
- Autonomous liquefaction allowed for easy, damage-free removal of bioelectrodes from hairy skin.
Conclusions:
- The developed transient hydrogel adhesive offers programmable adhesion and autonomous detachment for bioelectronic interfaces.
- This innovation facilitates stable and high-quality signal recording on hairy skin, simplifying bioelectronic device application and removal.
- The study presents a novel approach for designing advanced hydrogel adhesives for conformable and detachable bioelectronic applications.
