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Updated: May 10, 2025

A Straightforward Method for Glucosinolate Extraction and Analysis with High-pressure Liquid Chromatography HPLC
Published on: March 15, 2017
Polyprenylated acylphloroglucinols from Hypericum attenuatum and their antidepressant activities
En-Hui Zhang1, Dan Liu1, Yong Xiang1
1Department of Pharmacy, The 967th Hospital of Joint Logistic Support Force of PLA, Dalian116041, China.
Abstract:
Three new polycyclic polyprenylated acylphloroglucinols, attenuatumines A-C (1-3), were ioslated from the 90% EtOH extract of the air dried aerial parts of Hypericum attenuatum. Structural elucidation of all the compounds was performed by spectral methods such as 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy. All the isolated compounds were evaluated for their antidepressant activity by inhibiting reuptake of tritiated serotonin ([3H]-5-HT) and noradrenalinet ([3H]-NE) in rat brain synaptosomes. Compounds 2 exhibited some antidepressant activities in the [3H]-5-HT mode.
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