Tobacco smoking and sarcoidosis revisited-Evidence, mechanisms, and clinical implications: a narrative review
- Nadia Sweis 1, Arnaud Dominati 2,3, Supritha Prasad 2, Fatima Alnaimat 4, Mina Alawqati 2, Israel Rubinstein 5,6, Rachel Caskey 7
- Nadia Sweis 1, Arnaud Dominati 2,3, Supritha Prasad 2
- 1Department of Business Administration, Princess Sumaya University for Technology, Amman, Jordan.
- 2Division of Rheumatology, Department of Medicine, University of Illinois College of Medicine in Chicago, Chicago, IL, USA.
- 3Division of Clinical Immunology and Allergology, Department of Medicine, Geneva University Hospital, Geneva, Switzerland.
- 4Division of Rheumatology, Department of Internal Medicine, School of Medicine, University of Jordan, Amman, Jordan.
- 5Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois College of Medicine in Chicago, Chicago, IL, USA.
- 6Medical and Research Services, Jesse Brown VA Medical Center, Chicago, IL, USA.
- 7Division of Academic Internal Medicine, Department of Medicine, University of Illinois College of Medicine in Chicago, Chicago, IL, USA.
- 0Department of Business Administration, Princess Sumaya University for Technology, Amman, Jordan.
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View abstract on PubMed
Summary
This summary is machine-generated.Smoking
Area Of Science
- Immunology
- Pulmonology
- Epidemiology
Background
- Sarcoidosis is a multisystem inflammatory disease with unknown causes.
- Genetic and environmental factors, including smoking, are implicated.
- The role of smoking in sarcoidosis remains controversial.
Purpose Of The Study
- To review the complex relationship between smoking and sarcoidosis.
- To examine smoking's effects on immune modulation, disease presentation, and treatment response.
- To identify research gaps in understanding smoking's impact on sarcoidosis.
Main Methods
- Narrative review of existing literature.
- Analysis of studies on smoking, nicotine, and sarcoidosis.
- Examination of immune modulation and clinical outcomes.
Main Results
- Conflicting evidence exists regarding smoking's effect on sarcoidosis risk and severity.
- Nicotine exhibits both pro- and anti-inflammatory properties.
- Geographic, ethnic, and smoking history variations influence findings.
Conclusions
- The impact of smoking and nicotine on sarcoidosis is complex and multifaceted.
- Further research is needed to elucidate mechanisms of immune modulation and treatment outcomes.
- Clarifying smoking's role is crucial for sarcoidosis management.
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