Single nucleotide polymorphism analysis of 3'UTR rs713041 of Glutathione peroxidase 4 association with susceptibility to oral premalignant disorders
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View abstract on PubMed
Summary
This summary is machine-generated.The GPX4 3'UTR T/C genotype is linked to a higher risk of oral potentially malignant disorders (OPMDs), including oral submucous fibrosis (OSMF) and leukoplakia. This genetic marker may help predict OPMD development.
Area Of Science
- Genetics and Molecular Biology
- Oral Pathology
- Cancer Research
Background
- Oral potentially malignant disorders (OPMDs) are precursors to oral cancer.
- Glutathione peroxidase 4 (GPX4) is a key antioxidant enzyme and ferroptosis regulator implicated in cancer.
- Genetic variations in GPX4 may influence OPMD susceptibility.
Purpose Of The Study
- To investigate the association between the GPX4 3'UTR rs713041 single nucleotide polymorphism and OPMDs.
- To determine if this genetic variant is a risk factor for oral premalignancy.
Main Methods
- Genotyping of GPX4 3'UTR rs713041 using PCR-RFLP in 600 participants.
- Study included patients with oral submucous fibrosis (OSMF), leukoplakia, and healthy controls.
- Analysis of habitual factors such as chewing and smoking.
Main Results
- The heterozygous TC genotype of GPX4 rs713041 showed a significant association with OSMF (Odds Ratio = 2.42, P < 0.001).
- Chewing and smoking habits were prevalent in OSMF and leukoplakia cases.
- Disease prevalence differed between genders for OSMF and leukoplakia.
Conclusions
- The GPX4 3'UTR T/C carrier genotype is associated with an increased risk of OSMF and leukoplakia.
- This genotype may serve as a predictive biomarker for oral premalignancy disorders.
- Further research into genetic predispositions for OPMDs is warranted.
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