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Medication Induced Dyslipidemia in Children
Minali Patel1, Alejandro de la Torre2
1Department of Pharmacy, Cook Children's Medical Center, Fort Worth, TX, USA. minali.patel@cookchildrens.org.
Current Atherosclerosis Reports
|April 21, 2025
Summary
Pediatric dyslipidemia is rising, increasing atherosclerotic cardiovascular disease (ASCVD) risk. Non-lipid lowering medications can impact children
Area of Science:
- Pediatric Endocrinology
- Cardiovascular Medicine
- Pharmacology
Background:
- Pediatric dyslipidemia and cardiovascular disease (CVD) risk are increasing, with over 20% of children having a BMI > 95th percentile.
- Atherosclerosis evidence appears in childhood and progresses into adulthood.
- Unhealthy lifestyles and certain medications contribute to elevated lipids and lipoproteins in children.
Purpose of the Study:
- To review the impact of non-lipid lowering medications on lipid and lipoprotein metabolism in children under 18.
- To inform clinicians about medications that can adversely affect lipid levels in pediatric patients.
Main Methods:
- Literature review of studies on pediatric lipid metabolism and medication effects.
- Analysis of National Center for Health Statistics data on pediatric obesity and CVD risk.
- Identification of medication classes known to affect lipid levels in adults and children.
Main Results:
- Approximately 40.1% of children under 17 received at least one medication prescription in the past year.
- Medications including corticosteroids, retinoids, beta blockers, oral contraceptives, chemotherapy, antiretrovirals, and behavioral drugs can affect pediatric lipid profiles.
- Healthcare providers must consider medication side effects when evaluating pediatric lipid disorders.
Conclusions:
- Non-lipid lowering medications represent a significant secondary cause of dyslipidemia in children.
- Awareness of these drug effects is crucial for accurate diagnosis and management of pediatric lipid disorders.
- Further research is needed to understand the long-term impact of these medications on pediatric cardiovascular health.
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