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Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

34
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
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Transcranial Pulsed Current Stimulation and Social Functioning in Children With Autism: A Randomized Clinical Trial.

Zhenhuan Liu1, Sandra Zhong2,3, Roger C M Ho4,5

  • 1Department of Paediatrics, Nanhai Maternity and Children's Hospital Affiliated to Guangzhou University of Chinese Medicine, Foshan, Guangdong, China.

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Transcranial pulsed current stimulation (tPCS) significantly improved social functioning and sleep in children with autism spectrum disorder (ASD). This nonpharmacologic therapy offers a promising alternative for managing ASD symptoms.

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Area of Science:

  • Neuroscience
  • Pediatrics
  • Clinical Trials

Background:

  • Autism spectrum disorder (ASD) is a neurodevelopmental condition affecting social functioning and sleep.
  • Transcranial pulsed current stimulation (tPCS) is being investigated as a potential treatment for ASD.
  • Previous studies on tPCS for ASD were limited by small sample sizes and lack of sham controls.

Purpose of the Study:

  • To evaluate the safety and efficacy of tPCS in improving social functioning and sleep in children with ASD.
  • To conduct a rigorous, multicenter, sham-controlled randomized clinical trial.

Main Methods:

  • A multicenter, double-blind, sham-controlled randomized trial involving 312 children (aged 3-14) with ASD.
  • Participants received 20 sessions of active or sham tPCS over 4 weeks, with anode over the right cerebellar hemisphere and cathode over the left dorsolateral prefrontal cortex.
  • Social functioning (primary outcome) and sleep were assessed using standardized checklists.

Main Results:

  • Active tPCS showed a significantly greater improvement in social functioning compared to sham tPCS (P < .001).
  • Both active and sham tPCS were well-tolerated by participants.
  • Improvements were observed in social functioning and sleep after 20 tPCS sessions.

Conclusions:

  • Prefrontal-cerebellar tPCS is a safe and effective nonpharmacologic intervention for improving social functioning and sleep in children with ASD.
  • tPCS demonstrates potential as a viable therapeutic option for managing core symptoms of ASD.
  • This study provides robust evidence supporting the use of tPCS in pediatric ASD management.