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Updated: May 21, 2025

Human Placental and Decidual Organ Cultures to Study Infections at the Maternal-fetal Interface
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Published on: July 21, 2016

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Updates and Knowledge Gaps in Placenta Accreta Spectrum Biology

Lior Kashani-Ligumsky1, Olivia Scott1, Guadalupe Martinez1

  • 1Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology.

Clinical Obstetrics and Gynecology
|April 21, 2025
PubMed

Placenta accreta spectrum (PAS) disorders have traditionally been characterized based on histopathologic grading, emphasizing the invasion of trophoblasts into the myometrium, and uterine serosa. Recent research has shifted the etiological understanding of PAS, moving away from the concept of aggressive trophoblast invasion to focusing on the critical role of scarred decidual-myometrial interface. This shift highlights the importance of defective scar tissue as a primary factor, reshaping prevention strategies, diagnostic accuracy, and treatment approaches for this increasingly prevalent iatrogenic and morbid pregnancy complication.

Keywords:
accretacesareancollagenmatrixmorbidly adherent placentaobstetricsplacentapreviauterine dehiscence

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