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Olefin Metathesis Polymerization: Overview

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Recently, the development of olefin metathesis polymerization advanced the field of polymer synthesis. Simply put, the reorganization of substituents on their double bonds between two olefins in the presence of a catalyst is known as the olefin metathesis reaction. The use of metathesis reaction for polymer synthesis is called olefin metathesis polymerization.
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Updated: May 21, 2025

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

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Published on: September 26, 2016

Metathesis Depolymerization of a Fluorogenic Self-Immolative Polymer.

Gavin J Giardino¹, Jia Niu¹

¹Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, 02467 Massachusetts, United States.

ACS Macro Letters

|April 21, 2025

Summary

This summary is machine-generated.

This study introduces a self-immolative polymer (SIP) that becomes fluorescent when it breaks down. This innovative polymer offers enhanced sensitivity for molecular detection and signal amplification applications.

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Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

Area of Science:

Polymer Chemistry
Materials Science
Organic Chemistry

Background:

Self-immolative polymers (SIPs) offer unique degradation pathways.
Existing degradable polymers have limitations in signal amplification.
Need for sensitive detection and signal amplification tools.

Purpose of the Study:

To develop a novel self-immolative polymer (SIP) with a fluorescent response upon depolymerization.
To demonstrate the utility of this fluorogenic SIP for molecular detection and signal amplification.
To explore temperature-dependent fluorescence triggering.

Main Methods:

Synthesis of a self-immolative polymer (SIP) backbone.
Orthogonal functionalization of alkyne side chains using copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) chemistry.
Attachment of coumarin fluorophore and DABCYL quencher.
Depolymerization triggered by Grubbs 3rd-generation (G3) and Grubbs 2nd-generation (G2) organoruthenium initiators.

Main Results:

The developed SIP exhibits a fluorescence turn-on response upon metathesis depolymerization.
Efficient installation of coumarin and DABCYL moieties via CuAAC.
Achieved a fluorescence turn-on at nanomolar SIP concentrations.
Demonstrated temperature-dependent fluorescence turn-on using a thermally responsive G2 initiator.

Conclusions:

The synthesized fluorogenic SIP provides a sensitive platform for molecular detection and signal amplification.
Metathesis-triggered depolymerization of SIPs can lead to significant signal amplification.
The system shows potential for applications requiring tunable and responsive fluorescent signaling.