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Treatment outcomes of sinonasal adenoid cystic carcinoma: a single-center experience

  • 0Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School & Hwasun Hospital, Hwasun, Republic of Korea.
Oral Oncology +

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April 21, 2025

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April 21, 2025

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View abstract on PubMed

Summary

This summary is machine-generated.

Sinonasal adenoid cystic carcinoma (ACC) often presents at advanced stages and recurs frequently despite treatment. Tumor stage is the key factor influencing survival in these rare cancers.

Area Of Science

  • Oncology
  • Head and Neck Surgery
  • Medical Malignancies

Background

  • Sinonasal adenoid cystic carcinoma (ACC) is a rare malignancy with a propensity for perineural invasion and late recurrence.
  • This study analyzes clinical characteristics and treatment outcomes of sinonasal ACC patients over 15 years.

Discussion

  • Nasal obstruction is the most common symptom, with the maxillary sinus frequently involved.
  • Advanced stage at diagnosis (Stage IV) and perineural invasion are notable findings.
  • Multimodal treatment, primarily surgery followed by radiotherapy, is standard, though challenging in advanced cases.

Key Insights

  • High recurrence rates (64.7%) are observed, with a mean time to recurrence of approximately 53 months.
  • Tumor stage is identified as the sole significant prognostic factor for survival (p < 0.05).
  • Early detection and aggressive treatment are crucial for improving outcomes in sinonasal ACC.

Outlook

  • Further research into novel therapeutic strategies is warranted to combat the high recurrence rates.
  • Improved diagnostic methods for earlier detection could significantly impact patient survival.
  • Long-term surveillance is essential for patients with sinonasal ACC due to the risk of late recurrence.

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