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Information is everywhere and its presentation—such as how and when items are presented—can impact our perceptions and decisions surrounding the info. This broad concept umbrellas framing effects—influences that occur due to the way information is framed in its appearance, whether it’s purely the order or the specific wording of a message. Let’s take a look at numerous ways in which two versions of something can objectively say the same thing, yet we respond in...
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Related Experiment Video

Updated: May 10, 2025

The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time
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Reporting Modifications from the IMPACT-FH Study Using the FRAME-IS.

Christie Gilbert Klaczko1, Nicole L Walters1, Andrew Brangan1

  • 1Department of Genomic Health, Research Institute, Geisinger, Danville, Pennsylvania, USA.

Public Health Genomics
|April 21, 2025
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Summary
This summary is machine-generated.

Implementing cascade testing for Familial Hypercholesteremia (FH) requires adapting strategies. Reactive modifications to programs and tools like chatbots ensured successful screening for at-risk relatives.

Keywords:
Cascade testingFRAME-ISFamilial hypercholesterolemiaFamily communicationImplementation scienceModification

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Area of Science:

  • Genetics
  • Cardiology
  • Public Health

Background:

  • Familial Hypercholesteremia (FH) is a genetic disorder causing high LDL-cholesterol and severe cardiac risks.
  • FH is often undiagnosed, necessitating widespread screening programs.
  • Cascade testing is crucial for identifying at-risk relatives of FH patients.

Purpose of the Study:

  • To report modifications made to the IMPACT-FH cascade testing program.
  • To analyze how implementation strategies were adapted for FH screening.
  • To evaluate the role of flexibility in program implementation.

Main Methods:

  • The study analyzed modifications within the IMPACT-FH cascade testing program at Geisinger.
  • Implementation strategies included informational packets, chatbots, and direct contact.
  • The FRAME-IS framework was used to code modifications (nature, goal, timing, impact).

Main Results:

  • Eleven unplanned, reactive modifications were made during the implementation phase.
  • Changes optimized the program and strategies for FH families.
  • Modifications targeted the overall program (n=3), chatbot strategy (n=3), and direct contact (n=5).

Conclusions:

  • Flexibility and reactive modifications were essential for successful cascade testing implementation.
  • Adapting strategies enhances the effectiveness of FH screening programs.
  • The IMPACT-FH trial demonstrated the value of adaptable implementation in pragmatic research.