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Meta-Analysis of Influencing Factors of Mortality in Chinese Patients with Liver Failure Undergoing Plasma Exchange

Blood Purification +

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April 21, 2025

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April 21, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Key factors like older age and high MELD scores impact liver failure patient survival during plasma exchange (PE). Understanding these determinants can guide clinical care and improve outcomes for patients undergoing PE.

Area Of Science

  • Hepatology
  • Critical Care Medicine
  • Medical Statistics

Background

  • Liver failure poses a significant mortality risk.
  • Plasma exchange (PE) is a treatment option for liver failure.
  • Identifying mortality determinants in PE patients is crucial for improving care.

Purpose Of The Study

  • To evaluate factors influencing mortality in liver failure patients undergoing plasma exchange (PE).
  • To provide clinical guidance for optimizing patient survival.

Main Methods

  • Comprehensive literature search across multiple international and Chinese databases up to January 2024.
  • Meta-analysis using weighted mean difference for continuous and odds ratio for categorical variables.
  • Subgroup analyses based on liver failure type, PE volume, and HBV etiology.

Main Results

  • 33 studies with 5,842 patients were analyzed.
  • Older age, high MELD score, hepatic encephalopathy, cirrhosis, hepatorenal syndrome, peritonitis, elevated AST, low albumin, low prothrombin activity, prolonged PT, low platelets, and low WBC were associated with mortality.
  • Influencing factors varied by liver failure type and PE volume.

Conclusions

  • Demographic, liver function, coagulation, and routine blood indicators are linked to mortality in liver failure patients receiving PE.
  • Findings offer clinical guidance to enhance patient survival rates.
  • Further research may refine understanding of PE's role in liver failure management.