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Published on: April 23, 2012
Bioactive terpenoids and sterols from the fruiting bodies of Fomitopsis pinicola
Huan Yu1, Qian Chen1, Tian-Chi Xu1
1Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin, 300070, PR China.
Abstract:
A chemical investigation of the fruiting bodies of Fomitopsis pinicola was conducted, resulting in the isolation of 51 compounds, which included 16 previously undescribed lanostane triterpenes (1-14, 16-17), 30 known analogs (15, 18-46) as well as two sterols (47-48) and three diterpenes (49-51). Comprehensive analyses utilizing 1D, 2D NMR, MS and IR spectroscopy and DFT calculations of 13C NMR chemical shifts have elucidated the structures of the compounds in question. Two undescribed compounds in addition to fomitosides F, G and K showed cytotoxicity against MCF-7 cell line with IC50 values ranging from 11.01 to 31.92 μM. Meanwhile, these isolates showed α-glucosidase inhibitory activity, and compound 7 showed the IC50 value of 9.22 μM.
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