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Ceftazidime-induced urinary calculi in children: A case report
Quan Liu1, Zhike Huang, Kai Yi
1Department of Urology, Liuzhou Traditional Chinese Medical Hospital, Liuzhou, Guangxi Province, China.
Rationale:
Although drug-induced calculi are rare, numerous studies have reported on urinary tract stones caused by ceftriaxone, Urinary calculi induced by ceftazidime has only been reported in 1 study.
Patient Concerns:
The patient, an 8-year-old male, experienced pain in the lower right abdomen for 3 days and worsening fever for 1 day.The admission diagnosis was acute appendicitis.On the same day, the patient underwent laparoscopic appendectomy and was continuously given anti-infection treatment continuously by intravenous infusion of ceftazidime (1.0 g each time, every 8 hours, for 7 days). The patient's condition improved, and he was discharged. One day later, the patient was readmitted to the hospital due to right lumbar pain. An abdominal computed tomography scan revealed that the patient had right lower ureteral stones, right kidney stones, and hydrops in the right pelvis and upper ureter.
Diagnosis:
Ceftazidime-associated urinary calculus.
Interventions:
In terms of the treatment plan, we did not continue to use ceftazidime for anti-infection treatment. The patient was given 500 mL of normal saline through intravenous injection, a phloroglucinol spasmolytic injection, and 1500 mL of water a day.
Outcomes:
Three days later, the patient excreted small gravel in the urine,and the physical and chemical properties of the stones were analyzed to provide a reference for clinical treatment.
Lessons:
We consider the possibility of drug-induced stones and the need to stop the drug in time after this diagnosis. After conservative treatment, patients can generally heal themselves and avoid unnecessary surgical intervention.
