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Primary cardiac angiosarcoma with multiple pulmonary metastases: A case report.
Xing Yuan1,2, Xian-Ya Hu1,2, Wei-Min Li1,2
1Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Medicine
|April 21, 2025
Summary
Computed tomography-guided lung biopsy offers a safer alternative for diagnosing rare cardiac angiosarcoma. Chemotherapy with albumin-paclitaxel showed promising results in managing metastatic disease.
Area of Science:
- Cardiology
- Oncology
- Diagnostic Imaging
Background:
- Primary cardiac angiosarcoma is rare, aggressive, and difficult to diagnose.
- Biopsy of primary cardiac tumors carries significant risks.
- Effective early identification and management remain challenging.
Purpose of the Study:
- To evaluate computed tomography-guided lung metastasis biopsy as a safer diagnostic alternative for cardiac angiosarcoma.
- To propose a multidisciplinary approach for optimizing care in complex cases.
Main Methods:
- A case report of a 34-year-old male with cardiac angiosarcoma and lung metastases.
- Diagnosis confirmed via immunohistochemistry and gene testing (NRAS mutation).
- Treatment involved intravenous albumin-paclitaxel chemotherapy.
Main Results:
- The patient tolerated one cycle of albumin-paclitaxel.
- Symptoms improved, lung metastases shrank, and cardiac lesions stabilized after several cycles.
- Demonstrated a positive therapeutic response to albumin-paclitaxel.
Conclusions:
- CT-guided lung biopsy is a feasible diagnostic approach.
- Albumin-paclitaxel showed efficacy in metastatic cardiac angiosarcoma.
- Further studies are needed to confirm chemotherapy effectiveness in larger cohorts.
