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Energy Metabolism and Brain Aging: Strategies to Delay Neuronal Degeneration
Donghui Na1, Zechen Zhang2, Meng Meng1
1Department of Forensic Medicine, Hebei North University, Zhangjiakou, Hebei, China.
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Aging is characterized by a gradual decline in physiological functions, with brain aging being a major risk factor for numerous neurodegenerative diseases. Given the brain's high energy demands, maintaining an adequate ATP supply is crucial for its proper function. However, with advancing age, mitochondria dysfunction and a deteriorating energy metabolism lead to reduced overall energy production and impaired mitochondrial quality control (MQC). As a result, promoting healthy aging has become a key focus in contemporary research. This review examines the relationship between energy metabolism and brain aging, highlighting the connection between MQC and energy metabolism, and proposes strategies to delay brain aging by targeting energy metabolism.
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