Hydrate to keep the amyloid away

Despite older adults being more susceptible to dehydration, the relation between hydration and Alzheimer's disease and related dementias (ADRD) remains largely unexplored. A recent study by Jee Wook Kim and colleagues examined the association between daily fluid intake and ADRD neuroimaging biomarkers in 287 cognitively normal older adults. They found that lower daily fluid intake was associated with greater brain Aβ deposition and cerebrovascular injury. Here, we discuss the strengths and limitations of this study. We further highlight the potential for reverse causality and how hydration may play a role in the clinic and future ADRD research studies.