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RETRACTION: FOXA2 Suppresses Gallbladder Carcinoma Cell Migration, Invasion, and Epithelial-Mesenchymal Transition by

    Environmental Toxicology
    |April 22, 2025
    PubMed
    Abstract

    Insights

    This study investigated the role of FOXA2 in gallbladder carcinoma. It was found to suppress cancer cell migration and invasion by targeting SERPINB5, but the article has been retracted due to a compromised peer review process.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Cancer Research

    Background:

    • Gallbladder carcinoma is an aggressive malignancy with poor prognosis.
    • Understanding the molecular mechanisms underlying its progression is crucial for developing effective therapies.
    • The role of FOXA2 (Forkhead box protein A2) in gallbladder cancer progression requires further elucidation.

    Purpose of the Study:

    • To investigate the function of FOXA2 in suppressing gallbladder carcinoma cell migration, invasion, and epithelial-mesenchymal transition (EMT).
    • To identify SERPINB5 as a potential target gene regulated by FOXA2 in this context.

    Main Methods:

    • Cell culture and manipulation of FOXA2 expression.
    • Assessment of cell migration and invasion using wound healing and Transwell assays.
    • Analysis of epithelial-mesenchymal transition markers.
    • Investigation of SERPINB5 expression and its regulation by FOXA2.

    Main Results:

    • FOXA2 expression was found to inhibit gallbladder carcinoma cell migration and invasion.
    • FOXA2 suppressed the epithelial-mesenchymal transition process in these cells.
    • SERPINB5 was identified as a downstream target of FOXA2, mediating its suppressive effects.

    Conclusions:

    • FOXA2 acts as a tumor suppressor in gallbladder carcinoma by inhibiting cell migration, invasion, and EMT.
    • The FOXA2-SERPINB5 axis represents a potential therapeutic target for gallbladder cancer.
    • Note: This article has been retracted due to a compromised peer review process.

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