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Immunodeficiency Diseases

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Updated: May 10, 2025

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

Published on: September 13, 2024

Immunoengineering: An Emerging Field in Infectious Diseases.

Alexander M Tatara^1,2, Antonios G Mikos³, Dimitrios P Kontoyiannis⁴

¹Department of Biomedical Engineering, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.

The Journal of Infectious Diseases

|April 22, 2025

Summary

Immunoengineering precisely manipulates the immune system using biochemical and mechanical cues. This approach offers novel solutions for infectious diseases, including antimicrobial resistance and emerging pathogens.

Keywords:

chimeric antigen receptor immunoengineering immunotherapy scaffold vaccines

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Intranasal Administration of Recombinant Influenza Vaccines in Chimeric Mouse Models to Study Mucosal Immunity

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Area of Science:

Convergence of materials science, bioengineering, and immunology.
Emergence of immunoengineering as a paradigm to augment host immunity.

Background:

Cancer research has driven early immunoengineering discoveries.
Infectious diseases present significant clinical challenges, including antimicrobial resistance, emerging pathogens, and immunocompromised hosts.

Purpose of the Study:

To introduce basic concepts of immunoengineering.
To provide current examples of immunoengineering applications in infectious diseases.

Main Methods:

Delivering biochemical and mechanical cues with engineered precision.
Stimulating the immune system to respond to specific antigens with a designed phenotype.

Main Results:

Immunoengineering can be applied to address challenges in infectious diseases.
Examples include cell therapies, immunomodulating small molecule delivery, and next-generation vaccine development.

Conclusions:

Immunoengineering holds significant promise for combating infectious diseases.
Novel therapeutic strategies can be developed through the precise control of host immunity.