Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A hemodynamic model for anaphylactic shock.

W G Barsan, J R Hedges, S A Syverud

    Annals of Emergency Medicine
    |September 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Early treatment of acute ischemic stroke.

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015
    Same author

    Derivation of a clinical decision rule to guide the interhospital transfer of patients with blunt traumatic brain injury.

    Emergency medicine journal : EMJ·2005
    Same author

    Physician extenders in the emergency department.

    Emergency medicine journal : EMJ·2005
    Same author

    Electrocardiographic ST-segment elevation: the diagnosis of acute myocardial infarction by morphologic analysis of the ST segment.

    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine·2001
    Same author

    Soluble intercellular adhesion molecule-1 as a predictor of early adverse events in patients with chest pain compatible with myocardial ischemia.

    Annals of emergency medicine·2001
    Same author

    Influence of trauma system implementation on process of care delivered to seriously injured patients in rural trauma centers.

    Surgery·2001
    Same journal

    Do Hospitals Turn Away Ambulances Only When Busy, or When Their Peers Do?

    Annals of emergency medicine·2026
    Same journal

    "It's Just So Important to Make Them Feel Seen": Teen and Caregiver Perspectives of Lethal Means Safety Planning for the Emergency Department.

    Annals of emergency medicine·2026
    Same journal

    Hepatitis C Screening Among Persons Experiencing Homelessness in the Emergency Department: A Secondary Analysis of the Determining Effective Testing in Emergency Departments and Care Coordination on Treatment Outcomes (DETECT) for Hepatitis C (Hep C) Screening Trial.

    Annals of emergency medicine·2026
    Same journal

    Incidence and Outcomes of Emergency Physician-Performed Awake Intubations: A Report From the Airway Interventions Registry and Observational Database.

    Annals of emergency medicine·2026
    Same journal

    Variation in Emergency Department Experience With Pediatric Critical Illness.

    Annals of emergency medicine·2026
    Same journal

    Point-of-Care Ultrasound-Guided Hydrostatic Reduction of Ileocolic Intussusception in the Pediatric Emergency Department.

    Annals of emergency medicine·2026
    See all related articles

    Anaphylaxis causes rapid cardiovascular collapse in rabbits, with a significant drop in cardiac output and blood pressure. This animal model helps study anaphylactic shock and its effects on hemodynamics.

    Area of Science:

    • Cardiovascular Physiology
    • Immunology
    • Animal Models

    Background:

    • Anaphylactic shock treatment is largely empirical.
    • Hemodynamic alterations in anaphylaxis require further study.

    Purpose of the Study:

    • To develop a simple animal model for evaluating hemodynamic alterations in anaphylaxis.
    • To assess the impact of anaphylaxis on cardiac output and blood pressure.

    Main Methods:

    • Eight New Zealand white rabbits were sensitized with horse serum.
    • Anaphylactic shock was induced via a challenge dose of horse serum.
    • Cardiac output, arterial pressure, and temperature were monitored using catheters and thermodilution.

    Main Results:

    Related Experiment Videos

  • All animals exhibited a significant (P < .0005) fall in cardiac output, cardiac index, and blood pressure within three minutes.
  • Cardiac index decreased by 50% or more in all subjects.
  • Two animals succumbed to shock.

    • Conclusions:

    • The developed animal model effectively demonstrates rapid and severe hemodynamic compromise during anaphylaxis.
    • This model provides a basis for further research into the mechanisms and treatment of anaphylactic shock.