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Cancer Survival Analysis01:21

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Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
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Disaggregated Colorectal Cancer Mortality among Asian American Subgroups between 2005 and 2020.

Zeel Thakkar1,2, Mohammed A Khan1,3, Yan Wu1,4

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Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
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Colorectal cancer (CRC) mortality varies significantly among Asian American subgroups. This study highlights the need for disaggregated data to inform targeted prevention and intervention strategies for diverse Asian populations.

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Area of Science:

  • Epidemiology
  • Cancer Research
  • Health Disparities

Background:

  • Colorectal cancer (CRC) is a leading cause of cancer death among Asian Americans.
  • Significant heterogeneity exists within the Asian American population regarding cancer risk factors.
  • Prior research has largely overlooked CRC mortality variations across distinct Asian racial subgroups.

Purpose of the Study:

  • To analyze and compare colorectal cancer (CRC) mortality rates across disaggregated Asian American subgroups.
  • To identify trends and disparities in CRC mortality within the diverse Asian American population.
  • To provide data that can inform targeted public health interventions for specific Asian ethnic groups.

Main Methods:

  • Utilized US national mortality records (2005-2020) linked with American Community Survey data.
  • Calculated age-standardized mortality rates and standardized mortality ratios (SMR) for six major Asian subgroups.
  • Stratified analyses by sex, nativity, and CRC subsite (colon vs. rectum), comparing with Non-Hispanic Whites (NHWs).

Main Results:

  • Substantial heterogeneity in CRC mortality was observed among Asian subgroups compared to NHWs.
  • Asian Indian Americans exhibited the lowest CRC mortality rates, while Japanese Americans had the highest.
  • Korean and Vietnamese American CRC mortality rates increased over the study period, with Korean Americans showing the highest rates by 2020.

Conclusions:

  • Colorectal cancer (CRC) mortality patterns are not uniform across Asian American subgroups, underscoring the critical need for research that disaggregates this population.
  • The findings provide essential, subgroup-specific data on CRC mortality, enabling the development of tailored risk reduction strategies.
  • Addressing health disparities requires recognizing and responding to the unique epidemiological profiles of diverse racial and ethnic groups.