Related Experiment Video
Updated: May 12, 2025

Quantitative Determination of De Novo Fatty Acid Synthesis in Brown Adipose Tissue Using Deuterium Oxide
Published on: May 12, 2023
Acyl-CoA-binding proteins: bridging long-chain acyl-CoA metabolism to gene regulation
Allegra Wundersitz1, Kurt M V Hoffmann2, Joost T van Dongen1
1Department of Biology, Molecular Ecology of the Rhizosphere, RWTH Aachen University, 52074, Aachen, Germany.
Abstract:
Acyl-Coenzyme A-binding proteins (ACBPs) sequester and transport long-chain acyl-Coenzyme A (LCA-CoA) molecules, key intermediates in lipid metabolism, membrane biogenesis, and energy production. In addition, recent research emphasizes their regulatory role in linking the metabolic state to gene expression. In animals, ACBPs coordinate acetyl-CoA metabolism and enzyme activity, thereby affecting gene expression through broad signaling networks. In plants, ACBPs contribute to development and stress responses, with hypoxia research showing their involvement in detecting LCA-CoA fluctuations to trigger genetic acclimation. This review explores ACBPs in LCA-CoA signaling and gene regulation, emphasizing their function as universal 'translators' of metabolic states for cellular acclimation. Further ACBP research will offer novel regulatory insights into numerous signaling pathways fundamental to health, development, and environmental responses across kingdoms.
Related Concept Videos
Overview of Fatty Acid Metabolism
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
Co-activators and Co-repressors
Covalently Linked Protein Regulators
These groups modify specific amino acids in a protein....
Regulation of Metabolism
Regulation of Nuclear Protein Sorting
Cooperative Binding of Transcription Regulators

