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08:05
Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
Published on: December 19, 2020
Pulmonary and functional hallmarks after SARS-CoV-2 infection across three WHO severity level-groups: an
Patrícia Blau Margosian Conti1, Maria Ângela Gonçalves Oliveira Ribeiro1, Carla Cristina Souza Gomez1
1Department of Pediatrics, School of Medical Sciences, University of Campinas, Campinas, Brazil.
Frontiers in Medicine
|April 22, 2025
Summary
Pulmonary function and physical capacity decline after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, worsening with disease severity. Long-term lung damage and reduced function are evident in post-COVID-19 patients.
Area of Science:
- Pulmonology
- Infectious Diseases
- Rehabilitation Medicine
Background:
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection presents with diverse symptoms, impacting overall patient function.
- Post-infection consequences necessitate comprehensive short- and long-term functional assessments.
- Understanding the pulmonary sequelae of COVID-19 is crucial for patient recovery and management.
Purpose of the Study:
- To evaluate pulmonary function and structural changes in patients post-SARS-CoV-2 infection.
- To compare these characteristics across different clinical severity groups (mild/moderate, severe, critical).
- To identify long-term functional impairments resulting from COVID-19.
Main Methods:
- An observational, cross-sectional study included 210 participants evaluated at least 3 months post-COVID-19.
- A comprehensive battery of tests was employed: spirometry, impulse oscillometry, FeNO, CT scans, 6-minute walk test (6MWT), hand grip strength, and respiratory muscle pressures.
- Participants were categorized into mild/moderate (G1), severe (G2), and critical (G3) clinical presentation groups.
Main Results:
- Pulmonary function tests (FVC, FEV1, FEF25-75%) and fractional exhaled nitric oxide (FeNO) showed significant differences between groups, generally declining with increased disease severity.
- Chest CT revealed interstitial abnormalities correlating with COVID-19 severity.
- Functional capacity, assessed by 6MWT distance and hand grip strength, decreased progressively with higher disease severity (G3 < G1).
Conclusions:
- Post-COVID-19 patients exhibit altered pulmonary and functional markers that worsen with disease severity.
- Long-term pulmonary sequelae significantly impair functional capacity.
- Comprehensive functional assessments are vital for managing patients recovering from COVID-19.
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