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How the ghrelin receptor recognizes the acyl-modified orexigenic hormone

Yuki Shiimura1,2, Masayasu Kojima1, Takahiro Sato1

  • 1Division of Molecular Genetics, Institute of Life Science, Kurume University, Fukuoka, Japan.

Frontiers in Molecular Neuroscience
|April 22, 2025
PubMed
Summary

Ghrelin, a hormone regulating appetite and growth hormone, requires octanoylation for activity. Structural biology reveals how the ghrelin receptor recognizes this modified hormone, clarifying a long-standing molecular mystery.

Keywords:
GPCRghrelinghrelin receptor (GHS-R1a)orexigenic hormonestructural biochemistry

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