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Research progress in different physical therapies for treating peripheral nerve injuries
Xiao-Lei Chu1, Xiao-Xuan Zhao2, Shuai-Yi Liu2
1Department of Rehabilitation, Tianjin University Tianjin Hospital, Tianjin, China.
Frontiers in Neurology
|April 22, 2025
Summary
Physical therapy offers effective treatments for peripheral nerve injuries (PNI). Modalities like ultrasound, electrical stimulation, photobiomodulation, and exercise aid nerve regeneration and improve patient outcomes.
Area of Science:
- Neuroscience
- Rehabilitation Medicine
- Physical Therapy
Background:
- Peripheral nerve injury (PNI) research increasingly recognizes physical therapy's value.
- PNI treatment requires effective therapeutic strategies to promote nerve regeneration and functional recovery.
Purpose of the Study:
- To comprehensively review recent advancements, applications, and mechanisms of physical therapy modalities for PNI.
- To explore ultrasound, electrical stimulation, photobiomodulation, and aerobic exercise in PNI management.
Main Methods:
- Literature review of physical therapy modalities for peripheral nerve injuries.
- Analysis of ultrasound, electrical stimulation, photobiomodulation, and aerobic exercise mechanisms.
- Inclusion of other therapies like hyperbaric oxygen, magnetic, and biofeedback therapies.
Main Results:
- Ultrasound offers non-invasive neural modulation via mechanical and thermal effects.
- Electrical stimulation promotes nerve regeneration and mitigates muscle atrophy.
- Photobiomodulation and aerobic exercise enhance neuronal function and circulation.
Conclusions:
- Physical therapy provides theoretical and empirical support for PNI management.
- Further research is needed to standardize protocols, address individual variations, and assess long-term effectiveness.
- This review aims to advance research and clinical practice, improving patient quality of life and recovery.

