Related Experiment Video

Updated: May 10, 2025

Assays for Validating Histone Acetyltransferase Inhibitors
09:11

Assays for Validating Histone Acetyltransferase Inhibitors

Published on: August 6, 2020

6.4K

Mechanisms of HDACs in cancer development

Ying Zhang1, Haotian Wang1, Zhumei Zhan2

  • 1Department of Hematology, The First Hospital of Jilin University, Changchun, China.

Frontiers in Immunology
|April 22, 2025
PubMed

Insights

Histone deacetylase inhibitors (HDACis) show promise as epigenetic cancer therapies by halting cell growth and boosting immunity. Research focuses on selective inhibitors and combination treatments for better precision medicine outcomes.

Area of Science:

  • Epigenetics
  • Molecular Biology
  • Oncology

Background:

  • Histone deacetylases (HDACs) are epigenetic regulators crucial for cell functions.
  • HDAC inhibitors (HDACis) are emerging as targeted cancer therapies.
  • HDACis demonstrate antitumor effects via cell cycle arrest, apoptosis, and immune modulation.

Purpose of the Study:

  • To review the role of HDACs in tumor malignancy.
  • To assess the clinical progress of next-generation HDACis.
  • To provide insights into epigenetic-targeted cancer drug development.

Main Methods:

  • Systematic review of HDAC regulatory networks in cancer.
  • Analysis of clinical translation of novel HDAC inhibitors.
  • Evaluation of combination therapy strategies for HDAC inhibition.

Main Results:

  • HDACs are implicated in diverse tumor malignancy pathways.
  • Next-generation HDACis aim for improved selectivity and reduced off-target effects.
  • Combination therapies and subtype-specific strategies are key for overcoming resistance.

Conclusions:

  • HDACis represent a promising avenue for precision oncology.
  • Further research into selective HDAC inhibitors and combination strategies is warranted.
  • This review offers a framework for developing advanced epigenetic cancer therapies.
Keywords:
HDACicancerhistone acetyltransferaseshistone deacetylaseslymphoma

More Related Videos

Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS09:20

Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS

Published on: August 10, 2017

8.4K
Purification of H3 and H4 Histone Proteins and the Quantification of Acetylated Histone Marks in Cells and Brain Tissue09:43

Purification of H3 and H4 Histone Proteins and the Quantification of Acetylated Histone Marks in Cells and Brain Tissue

Published on: November 30, 2018

21.2K

Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
2.9K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.5K
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
12.8K
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.6K
Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
8.1K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.6K