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Related Experiment Video

Updated: May 10, 2025

Quantification of Breast Cancer Cell Invasiveness Using a Three-dimensional 3D Model

Quantification of Breast Cancer Cell Invasiveness Using a Three-dimensional 3D Model

Published on: June 11, 2014

Relationship between breast tissue involution and breast cancer.

Wenjing Li¹, Xian Zhao¹, Qinyu Han¹

¹Department of Breast Center, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, Shandong, China.

Frontiers in Oncology

|April 22, 2025

Summary

Breast tissue involution, the natural decrease in mammary gland tissue with age, is linked to breast cancer (BC) risk. Complete involution correlates with lower BC risk, while high mammographic density indicates increased risk.

Keywords:

TDLU breast cancer breast density breast involution mammary gland

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Last Updated: May 10, 2025

Quantification of Breast Cancer Cell Invasiveness Using a Three-dimensional 3D Model

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Published on: June 11, 2014

Orthotopic Injection of Breast Cancer Cells into the Mammary Fat Pad of Mice to Study Tumor Growth.

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Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

Published on: October 16, 2010

Area of Science:

Oncology
Radiology
Gerontology

Background:

Breast tissue involution is a natural aging process where mammary gland epithelial tissue diminishes.
The relationship between breast tissue involution and breast cancer (BC) risk is a growing area of research.
Mammographic density (MD) may serve as an indirect indicator of breast tissue involution.

Purpose of the Study:

To explore the association between breast tissue involution and breast cancer risk.
To review the biological process of breast tissue involution.
To elaborate on the connection between mammographic density and breast cancer.

Main Methods:

Literature review synthesizing existing research on breast tissue involution and BC.
Analysis of the relationship between mammographic density and breast cancer incidence.
Exploration of breast tissue involution as a potential risk factor for breast cancer.

Main Results:

Women with complete breast tissue involution exhibit a reduced risk of developing breast cancer.
Higher mammographic density is associated with a relatively greater risk of breast cancer.
Mammographic density may reflect the degree of breast tissue involution, aiding in risk stratification.

Conclusions:

Breast tissue involution is a significant factor influencing breast cancer risk.
Mammographic density is a valuable imaging parameter for assessing breast cancer risk.
Understanding involution patterns can help classify screening priorities for breast cancer.