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Minimum Inhibitory Concentration and Antibiotic Sensitivity Patterns in Pediatric Patients With Urinary Tract
Abhishek Ranjan1, Priya S Lakra1, Shyam S Sahu1
1Department of Pediatric Surgery, Rajendra Institute of Medical Sciences, Ranchi, IND.
Insights
Antibiotic resistance in pediatric urinary tract infections (UTIs) varies. This study identified common UTI pathogens and their sensitivities, recommending tailored antibiotic treatment based on local resistance patterns for effective management.
Area of Science:
- Pediatric infectious diseases
- Clinical microbiology
- Pharmacology
Background:
- Urinary tract infections (UTIs) in children present challenges in standardizing treatment due to varying antibiotic susceptibility.
- Understanding local bacterial profiles and antibiotic sensitivity is crucial for effective empirical management of pediatric UTIs.
Purpose of the Study:
- To assess antibiotic sensitivity patterns and identify bacterial profiles in pediatric patients diagnosed with UTIs.
- To provide data supporting empirical treatment strategies for children presenting with UTI symptoms.
Main Methods:
- An observational prospective study was conducted involving 384 pediatric patients at Rajendra Institute of Medical Sciences, Ranchi, India.
- Data collected included bacterial identification and in vitro antibiotic susceptibility testing for common UTI pathogens.
Main Results:
- Key pathogens identified included *Escherichia coli*, *Proteus* species, *Klebsiella* species, and *Pseudomonas* species.
- *Escherichia coli* demonstrated high sensitivity to ertapenem (93.1%) and meropenem (89.6%).
- Other effective antibiotics for *E. coli* included amikacin (81.3%), nitrofurantoin (79.3%), and imipenem (76.5%).
Conclusions:
- Significant variations exist in antibiotic sensitivity among bacterial strains causing pediatric UTIs.
- Antibiotic selection for UTIs should be guided by local antibiotic sensitivity data and specific patient profiles.
- Regional surveillance of antibiotic resistance patterns is essential for optimizing therapeutic choices in pediatric UTI management.
Abstract:
Background Clinical professionals find it challenging to set uniform standards for the treatment of urinary tract infections (UTIs) because of differences in susceptibility. This study has been conducted to assess antibiotic sensitivity patterns and bacterial profiles in pediatric patients with UTI and aid in the empirical management of patients exhibiting UTI symptoms. Materials and methods This is an observational prospective study conducted at the Department of Pediatric Surgery at Rajendra Institute of Medical Sciences (RIMS), Ranchi, Jharkhand, India. Overall, 384 patients were enrolled in the study. Ethical approval was obtained from the Institutional Ethics Committee (IEC), RIMS, Ranchi, Jharkhand, India, under letter number 308 dated April 4, 2024. Results There was no significant difference in age groups between male and female participants. Various bacterial pathogens were detected in pediatric UTIs, including Escherichia coli, Proteus species, Klebsiella species, Enterobacter species, Serratia species, Citrobacter species, and Pseudomonas species. Escherichia coli was more sensitive to ertapenem (135 (93.1%)) and meropenem (130 (89.6%)), followed by amikacin (118 (81.3%)), nitrofurantoin (115 (79.3%)), and imipenem (111 (76.5%)). Conclusion Different antibiotics have shown different levels of sensitivity toward various strains of bacterial pathogens causing UTIs. It is recommended that antibiotics as a medication be suggested on the basis of antibiotic sensitivity patterns in different cases of UTIs. Also, regional data may be effective in the selection of suitable drugs.
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