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Polypept(o)ide-Based Core-Shell Bottlebrush Polymers: A Versatile Platform for Drug Encapsulation.

Bonan Zhao1, Jingyuan Wei1, Rüdiger Berger2

  • 1Leiden Academic Center for Drug Research (LACDR), Leiden University, Einsteinweg 55, Leiden, 2333CC, The Netherlands.

Macromolecular Bioscience
|April 22, 2025
PubMed
Summary

This study introduces novel core-shell brushes (CSBs) synthesized from polypept(o)ides, demonstrating their potential as nanomedicine platforms. These versatile nanoparticles effectively encapsulate and release the drug dasatinib, showing therapeutic efficacy in glioblastoma cells.

Keywords:
core–shell bottlebrush polymersdrug deliverypolypept(o)ide“grafting‐from” synthesis

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