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Rapid chronic kidney disease progression in younger, First Nations patients in the Northern Territory

Winnie Chen1, Oyelola Adegboye1, Gillian Gorham1

  • 1Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.

Internal Medicine Journal
|April 22, 2025
PubMed

Insights

Younger First Nations patients with chronic kidney disease (CKD) face a higher risk of disease progression. Early intervention is crucial for those under 50 at risk of kidney replacement therapy or death.

Area of Science:

  • Public Health
  • Nephrology
  • Indigenous Health

Background:

  • Chronic kidney disease (CKD) disproportionately affects Indigenous populations globally.
  • Understanding CKD progression in remote Australian First Nations communities is vital for targeted healthcare strategies.

Purpose of the Study:

  • To investigate the progression of chronic kidney disease (CKD) in Australian First Nations patients.
  • To identify risk factors for advanced CKD, including kidney replacement therapy or death, in this population.

Main Methods:

  • A 6-year retrospective cohort study design was employed.
  • Data were collected from Australian First Nations patients residing in the remote Northern Territory.

Main Results:

  • Younger patients (under 50 years) exhibited a significantly higher risk of CKD progression compared to older adults.
  • The study identified age as a critical factor influencing the rate of progression to kidney replacement therapy or mortality.

Conclusions:

  • CKD progression is a significant concern for younger First Nations individuals.
  • Intervention strategies should prioritize early detection and management in at-risk younger populations to prevent severe outcomes.

Keywords:
Indigenous healthchronic kidney diseasedialysiskidney replacement therapyrural health services

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