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Identification of Eight Histone Methylation Modification Regulators Associated With Breast Cancer Prognosis

  • 0School of Artificial Intelligence, Anhui University of Science and Technology, Huainan, China.
Iet Systems Biology +

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April 22, 2025

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April 22, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

This study identifies eight key histone methylation regulators for breast cancer (BRCA) prognosis. The developed risk model predicts patient outcomes and aids in selecting targeted drug therapies.

Area Of Science

  • Epigenetics
  • Cancer Biology
  • Genomics

Background

  • Histone methylation is a crucial epigenetic process implicated in cancer development.
  • Histone methylation modification regulators (HMMRs) play a significant role in various cancers.

Purpose Of The Study

  • To develop a risk scoring model based on HMMRs for breast cancer (BRCA) prognosis.
  • To investigate the role of HMMRs in BRCA patient prognosis and drug sensitivity.

Main Methods

  • Differential expression analysis and univariate Cox regression identified survival-associated HMMRs.
  • LASSO regression constructed a risk scoring model using eight HMMRs.
  • Immune, functional, and drug sensitivity analyses were performed.

Main Results

  • A risk scoring model comprising eight HMMRs demonstrated independent predictive value.
  • The high-risk group exhibited a weakened immune response and altered gene expression in the nucleoplasm and tumor microenvironment.
  • The model showed potential for drug screening in BRCA patients.

Conclusions

  • The eight identified HMMRs are potential key factors for predicting prognosis and drug sensitivity in BRCA.
  • The risk model offers a tool for personalized treatment strategies in breast cancer.

Keywords:

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