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Related Concept Videos

Histone Modification02:32

Histone Modification

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
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Epigenetic Regulation01:46

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Master Transcription Regulators02:23

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Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
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Spreading of Chromatin Modifications02:25

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The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
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Histone Variants at the Centromere02:30

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Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
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Covalently Linked Protein Regulators02:04

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Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
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Updated: May 10, 2025

Methyl-binding DNA capture Sequencing for Patient Tissues
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Identification of Eight Histone Methylation Modification Regulators Associated With Breast Cancer Prognosis.

Yan-Ni Cao1, Xiao-Hui Li1, Xing-Jie Chen1

  • 1School of Artificial Intelligence, Anhui University of Science and Technology, Huainan, China.

IET Systems Biology
|April 22, 2025
PubMed
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This study identifies eight key histone methylation regulators for breast cancer (BRCA) prognosis. The developed risk model predicts patient outcomes and aids in selecting targeted drug therapies.

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cancerdata analysisdrugsstatistical analysis

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Area of Science:

  • Epigenetics
  • Cancer Biology
  • Genomics

Background:

  • Histone methylation is a crucial epigenetic process implicated in cancer development.
  • Histone methylation modification regulators (HMMRs) play a significant role in various cancers.

Purpose of the Study:

  • To develop a risk scoring model based on HMMRs for breast cancer (BRCA) prognosis.
  • To investigate the role of HMMRs in BRCA patient prognosis and drug sensitivity.

Main Methods:

  • Differential expression analysis and univariate Cox regression identified survival-associated HMMRs.
  • LASSO regression constructed a risk scoring model using eight HMMRs.
  • Immune, functional, and drug sensitivity analyses were performed.

Main Results:

  • A risk scoring model comprising eight HMMRs demonstrated independent predictive value.
  • The high-risk group exhibited a weakened immune response and altered gene expression in the nucleoplasm and tumor microenvironment.
  • The model showed potential for drug screening in BRCA patients.

Conclusions:

  • The eight identified HMMRs are potential key factors for predicting prognosis and drug sensitivity in BRCA.
  • The risk model offers a tool for personalized treatment strategies in breast cancer.