Related Experiment Video
Updated: May 10, 2025

JenaTron - An Experimental Approach to Study the Effects of Plant History and Soil History on Grassland Ecosystem Functioning
Published on: March 21, 2025
The ahpC c-54t compensatory mutation is not always a valid surrogate for isoniazid resistance in Mycobacterium
Viktória Szél1, Jody E Phelan2, Sophia B Georghiou3
1National Reference Laboratory for Mycobacteriology, National Koranyi Institute of Pulmonology, Budapest, Hungary.
Abstract:
Thirteen commercial genotypic antimicrobial susceptibility assays interrogate mutations upstream of ahpC to infer isoniazid resistance for Mycobacterium tuberculosis. We demonstrate that relying on one of these compensatory mutations (i.e., ahpC c-54t)-rather than causative resistance mutations in katG that ahpC compensates for-can result in systematic false-resistant results for isoniazid with the Cepheid Xpert MTB/XDR and suboptimal treatment. The WHO mutation catalog should be refined to address this scenario.
Related Concept Videos
The Delta-to-Y Circuit
The Thyroid Gland
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The Muscular System
The Ideal Diode
The Delta-to-Delta Circuit
The ADP/ATP Carrier Protein

