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Site-Defined High-Loading Tellurium Single-Atom Nanozymes Anchored on Checkerboard-Patterned Graphyne for Sensor

Jianing Xia1, Jian Guo1, Zhen Li1

  • 1Department of Chemistry & Institute for Sustainable Energy, College of Sciences, Shanghai University, Shanghai, 200444, P. R. China.

Small (Weinheim an Der Bergstrasse, Germany)
|April 22, 2025
PubMed
Summary

Site-defined single-atom tellurium nanozymes (Te SAN) demonstrate enhanced peroxidase-like activity. This innovation in nanozyme design shows potential for sensitive bisphenol detection in food safety applications.

Keywords:
graphynesensor arrayssingle‐atom nanozymessite‐defined tellurium doping

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Catalysis

Background:

  • Single-atom nanozymes mimic natural metalloenzymes, offering unique catalytic properties.
  • The design of anchoring sites is crucial for controlling nanozyme loading capacity and activity.
  • Tellurium single-atom nanozymes (Te SAN) leverage specific active centers for enhanced performance.

Purpose of the Study:

  • To synthesize and characterize a site-defined tellurium single-atom nanozyme (Te SAN) using para-nitrogen-doped graphyne.
  • To investigate the peroxidase-like activity of Te SAN and elucidate the underlying catalytic mechanism.
  • To develop a Te SAN-based sensor for the detection of bisphenols in food safety monitoring.

Main Methods:

  • Synthesis of para-nitrogen-doped graphyne with diamond cavities as a support material.
  • Anchoring single-atom tellurium onto the graphyne support to create Te SAN.
  • Evaluation of peroxidase-like activity and bisphenol detection using a sensor array.
  • Density functional theory (DFT) calculations to understand the catalytic mechanism.

Main Results:

  • Achieved a high tellurium loading of 19.21 wt.% in Te SAN due to pre-designed anchoring sites.
  • Demonstrated significant peroxidase-like activity of Te SAN.
  • DFT calculations revealed that Te doping lowers the Gibbs free energy barrier for •OH formation, enhancing catalytic activity.
  • Successfully identified five bisphenols using a Te SAN-based sensor array, indicating potential for food safety analysis.

Conclusions:

  • Site-defined single-atom nanozymes offer precise control over synthesis and enhanced catalytic activity.
  • Te SAN exhibits excellent peroxidase-like activity and serves as a promising platform for bisphenol detection.
  • The strategy for designing anchoring sites provides a new approach for developing advanced nanozymes.