Related Experiment Video
Updated: Jun 19, 2026
Transient Expression in Nicotiana Benthamiana Leaves for Triterpene Production at a Preparative Scale
Published on: August 16, 2018
Bioactive Sesterterpenoids from the Mangrove-Derived Aspergillus sp. GXIMD 03023
Jia-Li He1,2, Yu Wang3,2, Xiang-Xi Yi3,1,2
1University Engineering Research Center of High-efficient Utilization of Marine Traditional Chinese Medicine Resources, Nanning 530200, P. R. China.
Abstract:
Four novel sesterterpenoids, asperterpenoids Q-T (1-4), featuring a rare 5/7/(3)6/5 pentacyclic skeleton were isolated from the mangrove-derived fungus Aspergillus sp. GXIMD 03023 using an NMR-guided approach. Their structures and absolute configurations were determined by comprehensive spectroscopic analysis, including 1D/2D-NMR and HRESIMS, supplemented by experimental and ECD spectral matching, DFT-calculated 13C NMR chemical shifts, and DP4plus probability analysis. Compounds 1-4 were screened for antibacterial activity and benign prostatic hyperplasia (BPH) inhibitory activity. Compound 1 showed weak activity against Vibrio harveyi and Xanthomonas campestris, with MIC values of 3.12 and 6.25 μg/mL, respectively. Compound 3 had significant inhibitory activity against BPH with an IC50 value of 3.68 μM.
More Related Videos
07:59A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
11:44Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
Published on: January 19, 2022
