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Systemic availability of oral slow-release morphine in man
Annals of Clinical Biochemistry
|May 1, 1985
Summary
This study found that oral morphine (MST Continus) has high systemic availability, similar to intravenous morphine, with low metabolism. This suggests effective oral absorption and reduced liver processing of morphine.
Area of Science:
- Pharmacokinetics
- Clinical Pharmacology
- Drug Metabolism
Background:
- Morphine is a key analgesic, but its oral bioavailability can be variable.
- Understanding the pharmacokinetics of oral morphine formulations is crucial for effective pain management.
Purpose of the Study:
- To compare plasma morphine concentrations after intravenous and oral MST Continus administration.
- To determine the oral systemic availability and clearance of morphine.
Main Methods:
- A within-patient crossover study involving twelve participants.
- Administration of intravenous morphine sulfate followed by oral MST Continus (morphine sulfate) at different dose regimens.
- Measurement of plasma morphine concentrations over 48 hours.
Main Results:
- Systemic clearance of morphine was consistently low (approximately 3 ml/min/kg) for both intravenous and oral routes.
- The area under the concentration-time curve ratio for oral MST Continus to intravenous morphine was approximately 1:1 for 20 mg doses.
- A significantly higher ratio was observed for 10 mg doses, indicating greater oral availability at this lower dose.
Conclusions:
- Oral MST Continus demonstrates high systemic availability of morphine.
- Low hepatic metabolism of morphine is suggested by the study findings.
- The results support the efficacy of oral MST Continus for morphine delivery.