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Periorbital Dermatitis Induced by Apixaban.

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Periorbital dermatitis, a rare adverse drug reaction, can be caused by apixaban. Discontinuing apixaban and switching to rivaroxaban resolved a patient's severe symptoms.

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Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Periorbital dermatitis is infrequently associated with adverse drug reactions.
  • Apixaban is an anticoagulant medication.
  • This case highlights a rare adverse effect of apixaban.

Observation:

  • A 76-year-old female developed severe periorbital dermatitis three weeks after initiating apixaban.
  • Previous treatments including antihistamines, topical steroids, calcineurin inhibitors, and emollients were ineffective over 20 months.
  • Symptom resolution occurred after discontinuing apixaban and switching to rivaroxaban.

Findings:

  • Periorbital dermatitis is identified as a rare, previously underreported adverse effect of apixaban.
  • This represents the second reported case of apixaban-induced periorbital dermatitis in medical literature.

Implications:

  • Clinicians should consider apixaban as a potential cause of periorbital dermatitis.
  • Increased awareness of this adverse drug effect is crucial for accurate diagnosis and management.
  • Drug side effects should be included in the differential diagnosis for new-onset skin conditions.