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Updated: May 10, 2025

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

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Published on: June 14, 2021

RETINAL VESSELS WHITENING IN RETINITIS PIGMENTOSA.

Shaden H Yassin¹, Naomi E Wagner, Fritz Gerald P Kalaw

¹Viterbi Family Department of Ophthalmology, Shiley Eye Institute, University of California, San Diego, California.

Retina (Philadelphia, Pa.)

|April 22, 2025

Summary

This summary is machine-generated.

Retinal vessel whitening (RVW) is common in retinitis pigmentosa (RP), appearing in 38% of patients. This finding is linked to reduced retinal thickness and may serve as a marker for RP severity.

Keywords:

retinal vasculature retinal vessel whitening retinitis pigmentosa ultra-widefield imaging

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Published on: December 12, 2014

Area of Science:

Ophthalmology
Retinal Imaging
Medical Research

Background:

Retinitis pigmentosa (RP) is a group of inherited disorders characterized by progressive vision loss.
Retinal vessel whitening (RVW) is a clinical sign that can indicate various retinal pathologies.

Purpose of the Study:

To characterize the prevalence and features of retinal vessel whitening (RVW) in patients with retinitis pigmentosa (RP).

Main Methods:

A single-center, cross-sectional study involving the review of clinical notes and ultra-widefield imaging of 116 patients with confirmed RP.
Data collected included best-corrected visual acuity, presence, absence, and location of RVW, which were correlated with disease characteristics.

Main Results:

RVW was observed in 38% of the 116 RP patients, predominantly in the inferotemporal quadrant.
Eyes with RVW showed significantly reduced total retinal thickness (mean difference 151.7 µm) and thinning of both inner and outer retinal layers.
A significant association was found between the number of quadrants affected by RVW and the degree of retinal thickness reduction.

Conclusions:

Retinal vessel whitening is a common finding in RP and should be considered a phenotypic feature of the disease.
RVW is associated with structural changes in the central macula, suggesting its potential as a marker for RP severity.