Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human telencephalic angiogenesis.

K C Kuban, F H Gilles

    Annals of Neurology
    |June 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    This study details the development of human brain blood vessels during late gestation. Key findings show how vessel branching and muscularization patterns change as the brain grows, particularly in the striatum.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Neonatal white matter damage and the fetal inflammatory response.

    Seminars in fetal & neonatal medicine·2020
    Same author

    Abnormal cerebral microstructure in premature neonates with congenital heart disease.

    AJNR. American journal of neuroradiology·2013
    Same author

    Early postnatal hypotension is not associated with indicators of white matter damage or cerebral palsy in extremely low gestational age newborns.

    Journal of perinatology : official journal of the California Perinatal Association·2011
    Same author

    Abnormal microstructure of the atrophic thalamus in preterm survivors with periventricular leukomalacia.

    AJNR. American journal of neuroradiology·2010
    Same author

    Quantitative short echo time 1H-MR spectroscopy of untreated pediatric brain tumors: preoperative diagnosis and characterization.

    AJNR. American journal of neuroradiology·2006
    Same author

    Abducens length and vulnerability?

    Neurology·2004

    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Vascular Biology

    Background:

    • The development of the human brain's vascular system is crucial for its growth and function.
    • Understanding the histogenesis and regional development of the telencephalic microvasculature provides insights into neurodevelopmental processes.

    Purpose of the Study:

    • To provide new observations on the histogenesis and regional development of the human telencephalic microvasculature during the last half of gestation.
    • To describe the morphological changes and branching patterns of cerebral blood vessels during fetal brain development.

    Main Methods:

    • Histological examination of human fetal brain tissue during the last half of gestation.
    • Detailed observation and analysis of microvascular structures, including vessel courses, branching angles, and muscularization patterns.

    Related Experiment Videos

    Main Results:

    • Persistent endothelium-lined trunks from pia to the subventricular plexus were observed throughout late gestation.
    • Increasing numbers of shorter penetrating vessels supply new cerebral tissue, with complex modifications in vessel courses as the brain grows.
    • Extrastriatal vessels exhibit lateral and acute-angle branching, while striatal vessels predominantly show acute angles. Muscularization of extrastriatal vessels occurs late, whereas striatal arteries begin to muscularize around 24 weeks of gestation, progressing centripetally.

    Conclusions:

    • The study elucidates the dynamic development of the human telencephalic microvasculature during late fetal development.
    • Distinct regional differences in vascular branching and the timing of muscularization (striatum vs. extrastriatal regions) are highlighted.
    • The findings contribute to a better understanding of the vascular basis of human brain growth and maturation.