Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neuronal Communication01:28

Neuronal Communication

811
Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...
811
Synaptic Signaling01:09

Synaptic Signaling

5.5K
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
5.5K
Neurochemical Transmission: Sites of Drug Action01:26

Neurochemical Transmission: Sites of Drug Action

2.2K
Neurochemical transmission, the conduction of electrical impulses between neurons mediated by neurotransmitters, plays a vital role in various physiological processes. Autonomic drugs exert their effects by modulating neurotransmission within the autonomic nervous system. For instance, drugs such as hemicholinium block the precursor uptake necessary for synthesizing acetylcholine, an essential autonomic neurotransmitter. Following synthesis, neurotransmitters are stored in vesicles. Metyrosine...
2.2K
The Synapse02:47

The Synapse

124.6K
Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.
124.6K
Postsynaptic Potential (PSP)01:32

Postsynaptic Potential (PSP)

2.4K
Postsynaptic potential (PSP) refers to a change in the electrical potential of a neuron when neurotransmitters released by presynaptic neurons bind to postsynaptic receptors. This potential can either be excitatory, leading to depolarization and ultimately action potential generation, or inhibitory, leading to hyperpolarization and suppression of the postsynaptic neuron.
There are two types of receptors: ionotropic and metabotropic.
The ionotropic receptor is the membrane protein that has an...
2.4K
Neural Circuits01:25

Neural Circuits

1.1K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>C. elegans</i> somatostatin/allatostatin C signaling regulates sleep, metabolism, survival, and memory via a sleep-active neuron.

Science advances·2026
Same author

Autocrine feedback maintains homeostatic neuropeptide expression in a peptidergic hub neuron.

bioRxiv : the preprint server for biology·2026
Same author

A gene expression atlas of a juvenile nervous system.

bioRxiv : the preprint server for biology·2025
Same author

<i>Ce</i> -NeRV3D - a <i>C. elegans</i> Neuron RNA-seq Visualization tool in 3D.

microPublication biology·2025
Same author

Biodiversity2Drugs-Renaissance of exploring nature-derived peptides for GPCR ligand discovery.

British journal of pharmacology·2025
Same author

Divergence in neuronal signaling pathways despite conserved neuronal identity among Caenorhabditis species.

Current biology : CB·2025

Related Experiment Video

Updated: Jun 14, 2025

Multi-Faceted Mass Spectrometric Investigation of Neuropeptides in Callinectes sapidus
09:22

Multi-Faceted Mass Spectrometric Investigation of Neuropeptides in Callinectes sapidus

Published on: May 31, 2022

2.4K

Mapping and decoding neuropeptide signaling networks in nervous system function.

Isabel Beets1, Jan Watteyne1

  • 1Department of Biology, University of Leuven, Leuven, Belgium.

Current Opinion in Neurobiology
|April 22, 2025
PubMed
Summary
This summary is machine-generated.

Neuropeptides are key brain signaling molecules. Mapping their networks reveals conserved features and new tools enable mechanistic studies of their complex roles in behavior.

More Related Videos

Single Cell Multiplex Reverse Transcription Polymerase Chain Reaction After Patch-clamp
10:44

Single Cell Multiplex Reverse Transcription Polymerase Chain Reaction After Patch-clamp

Published on: June 20, 2018

9.8K
Mapping Inhibitory Neuronal Circuits by Laser Scanning Photostimulation
09:50

Mapping Inhibitory Neuronal Circuits by Laser Scanning Photostimulation

Published on: October 6, 2011

17.2K

Related Experiment Videos

Last Updated: Jun 14, 2025

Multi-Faceted Mass Spectrometric Investigation of Neuropeptides in Callinectes sapidus
09:22

Multi-Faceted Mass Spectrometric Investigation of Neuropeptides in Callinectes sapidus

Published on: May 31, 2022

2.4K
Single Cell Multiplex Reverse Transcription Polymerase Chain Reaction After Patch-clamp
10:44

Single Cell Multiplex Reverse Transcription Polymerase Chain Reaction After Patch-clamp

Published on: June 20, 2018

9.8K
Mapping Inhibitory Neuronal Circuits by Laser Scanning Photostimulation
09:50

Mapping Inhibitory Neuronal Circuits by Laser Scanning Photostimulation

Published on: October 6, 2011

17.2K

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Systems Biology

Background:

  • Neuropeptides are crucial signaling molecules in the brain, regulating diverse functions.
  • Advances in expression profiling and receptor interaction studies enable neuropeptide signaling network mapping.

Purpose of the Study:

  • To review recent advances in mapping neuropeptide signaling networks.
  • To highlight technical breakthroughs in sensing neuropeptide activity in vivo.
  • To discuss the dynamic nature of neuropeptide network architecture.

Main Methods:

  • Reconstruction of neuropeptide signaling networks in mammalian and C. elegans models.
  • Biochemical characterization of neuropeptide-receptor interactions.
  • Development of in vivo sensors for peptide release, receptor binding, and intracellular signaling.

Main Results:

  • Conserved organizational features of neuropeptidergic networks across species.
  • Emerging tools provide mechanistic insights into neuropeptide signaling.
  • Neuropeptide network architecture exhibits plasticity across evolution and individual lifespan.

Conclusions:

  • Neuropeptide signaling networks display conserved principles but also dynamic changes.
  • New technologies are facilitating a deeper mechanistic understanding of these networks.
  • Understanding neuropeptide network complexity is essential for deciphering their role in behavior.