Chromatin regulation of neuronal activity-dependent gene programs in circuit formation and plasticity

Neuronal activity-dependent transcription is crucial for the development and plasticity of neuronal circuits. At the chromatin level, the induction of neuronal activity-regulated genes is orchestrated through various mechanisms, including the deposition of histone modifications at regulatory elements, the binding of transcriptional activators and repressors, chromatin remodeling, and the control of 3D genome architecture. Here, we review our current understanding of how chromatin mechanisms regulate temporally distinct transcriptional waves following neuronal stimulation and allow neurons to mount cell type-specific and stimulus-specific transcriptional responses. We also highlight a specific epigenetic mechanism in developing neurons that maintains immediate early genes (IEGs) in an inactive though poised state, while simultaneously preparing them for rapid activation in response to sensory stimulation. We discuss how chromatin regulation mechanisms play a crucial role in controlling activity-regulated gene expression, enabling the implementation of precise gene expression programs during different stages of neural circuit development and plasticity.