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Related Experiment Video

Updated: May 21, 2025

Murine Orchiectomy and Ovariectomy to Reduce Sex Hormone Production
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Testosterone Deprivation Impairs Cardiac Systolic Function in Orchiectomized Wistar Rats.

Gabriela Almeida Motta1, Graziele Halmenschlager1,2, Rachel Pinto Dornelles Dutra1

  • 1Biociências, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Brazil.

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|April 22, 2025
PubMed
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Testosterone deficiency in rats impaired cardiac systolic function, indicated by reduced fractional shortening and altered mitral valve closure time. This study highlights testosterone

Area of Science:

  • Cardiovascular Physiology
  • Endocrinology
  • Male Reproductive System

Background:

  • Low testosterone levels are associated with cardiac disease and cardiovascular mortality.
  • The precise impact of testosterone deficiency on cardiac systolic function and morphology remains unclear.

Purpose of the Study:

  • To investigate the effects of testosterone deprivation on cardiac systolic function and morphology in male Wistar rats.

Main Methods:

  • Male Wistar rats were divided into sham operation and orchiectomized groups.
  • Echocardiographic parameters were assessed to evaluate left ventricle (LV) systolic function and morphology.
  • Serum testosterone levels were analyzed before and after surgery.

Main Results:

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  • Orchiectomized rats exhibited reduced LV fractional shortening, increased myocardial performance index (MPI), prolonged mitral valve closure time, and decreased heart rate compared to controls.
  • No significant difference in ejection fraction was observed between groups.
  • Heart weight was significantly lower in the orchiectomized group.

Conclusions:

  • Testosterone deprivation negatively impacts cardiac systolic function, affecting contraction and relaxation parameters.
  • Testosterone deficiency alters heart rate and heart weight.
  • This study is the first to demonstrate that reduced testosterone levels can alter specific cardiac parameters like mitral valve closing time and MPI.