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Testosterone Deprivation Impairs Cardiac Systolic Function in Orchiectomized Wistar Rats
Gabriela Almeida Motta1, Graziele Halmenschlager1,2, Rachel Pinto Dornelles Dutra1
1Biociências, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Brazil.
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|April 22, 2025
Summary
Testosterone deficiency in rats impaired cardiac systolic function, indicated by reduced fractional shortening and altered mitral valve closure time. This study highlights testosterone
Area of Science:
- Cardiovascular Physiology
- Endocrinology
- Male Reproductive System
Background:
- Low testosterone levels are associated with cardiac disease and cardiovascular mortality.
- The precise impact of testosterone deficiency on cardiac systolic function and morphology remains unclear.
Purpose of the Study:
- To investigate the effects of testosterone deprivation on cardiac systolic function and morphology in male Wistar rats.
Main Methods:
- Male Wistar rats were divided into sham operation and orchiectomized groups.
- Echocardiographic parameters were assessed to evaluate left ventricle (LV) systolic function and morphology.
- Serum testosterone levels were analyzed before and after surgery.
Main Results:
- Orchiectomized rats exhibited reduced LV fractional shortening, increased myocardial performance index (MPI), prolonged mitral valve closure time, and decreased heart rate compared to controls.
- No significant difference in ejection fraction was observed between groups.
- Heart weight was significantly lower in the orchiectomized group.
Conclusions:
- Testosterone deprivation negatively impacts cardiac systolic function, affecting contraction and relaxation parameters.
- Testosterone deficiency alters heart rate and heart weight.
- This study is the first to demonstrate that reduced testosterone levels can alter specific cardiac parameters like mitral valve closing time and MPI.
