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Related Experiment Videos

Histamine: a role in normal drinking.

F S Kraly

    Appetite
    |June 1, 1985
    PubMed
    Summary

    Histamine plays a role in drinking behavior around mealtimes. This study supports a vagally-mediated, histaminergic pathway in rats that triggers drinking before food absorption.

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    Area of Science:

    • Physiology
    • Neuroscience
    • Gastroenterology

    Background:

    • Physiological mechanisms of normal drinking, especially around mealtime, are not well understood.
    • Recent research explores the role of histamine in food-elicited drinking.

    Purpose of the Study:

    • To investigate the physiological mechanisms controlling mealtime drinking.
    • To evaluate the role of histamine in drinking behavior triggered by eating.

    Main Methods:

    • Experiments were conducted on rats.
    • The study focused on preabsorptive and pregastric drinking components.
    • Vagal mediation and histaminergic pathways were examined.

    Main Results:

    • Findings support a hypothesis involving histamine in drinking elicited by eating.
    • Evidence suggests a preabsorptive, pregastric, vagally-mediated, histaminergic component.

    Conclusions:

    • Histamine is implicated in the control of drinking behavior associated with eating.
    • A specific neural pathway involving the vagus nerve and histamine regulates pre-meal drinking in rats.

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