Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanical Protein Function01:58

Mechanical Protein Function

Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force. 
Mechanical Efficiency of Real Machines01:14

Mechanical Efficiency of Real Machines

The mechanical efficiency of a machine is a fundamental concept that describes how effectively a machine can convert input work into output work. According to this concept, the efficiency of a machine is equal to the ratio of the output work to the input work. An ideal machine, meaning a machine that has no energy losses, has an efficiency of one. This implies that the input work and the output work are equal.
However, in reality, no machine can be truly ideal, and all of them experience some...
Mechanistic Models: Overview of Compartment Models01:21

Mechanistic Models: Overview of Compartment Models

Mechanistic models, a category encompassing both physiological and compartmental modeling, differ from empirical models' approaches to incorporating known factors about the systems being modeled. Empirical models describe data with minimal assumptions, while mechanistic models aim to provide a robust description of available data by specifying assumptions and integrating known factors about the system. Compartmental analysis is a key example of a mechanistic model in pharmacokinetics and...
Pore Size Distribution01:23

Pore Size Distribution

In concrete, the pore size distribution significantly influences the material's properties. Capillary pores, markedly larger than gel pores, form a vast network within partially hydrated cement paste, reducing the concrete's strength and increasing its permeability. This heightened permeability leads to a greater risk of damage from environmental factors like freeze-thaw cycles and chemical attacks, with the extent of vulnerability also being tied to the water-to-cement ratio.
Adequate...
Typical Model Studies01:30

Typical Model Studies

Fluid mechanics model studies often utilize scaled-down systems to predict fluid behavior in full-scale environments, such as river flows, dam spillways, and structures interacting with open surfaces. Maintaining Froude number similarity in river models is crucial, as it replicates surface flow features like wave patterns and velocities.
Multiple Pipe Systems01:21

Multiple Pipe Systems

Multipipe systems consist of complex configurations of interconnected pipes designed to transport fluids efficiently across intricate networks. They are essential in engineering applications requiring precise control over flow distribution, pressure, and head loss. They are categorized into series, parallel, loop, and network configurations, each distinguished by unique flow characteristics and applications.
Series Configuration
In a series configuration, fluid flows sequentially from one pipe...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

E. coli Extracellular Matrix: A Tunable Composite With Hierarchical Structure.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Plant-Based Matrix for Bone Apatite Biomineralization: In Vitro Bioactivity, Biocompatibility, and Degradability of Lignin and Lignin-Silica Composites.

ACS biomaterials science & engineering·2026
Same author

Murine model of high bone mass osteogenesis imperfecta exhibits bone matrix hyper-mineralization, misaligned mineral crystals, and altered osteoblast differentiation.

Bone research·2026
Same author

Fibrin defines tissue stiffness and biomechanical signaling in regenerating zebrafish hearts as revealed by high-resolution stiffness mapping.

iScience·2026
Same author

Conductive Hydrogels for Exogenous Sensing and Cell Fate Control.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Nano-scale evidence for osteocyte network integration across bone remodeling interfaces in human bone revealed by synchrotron nanoCT.

Materials today. Bio·2026
Same journal

Interplay between oxygen redox and interfacial stability of Li-rich positive electrodes in sulfide-based all-solid-state batteries.

Nature communications·2026
Same journal

Breaking dependence on melanisation imparts diversity to a dogmatic invasion strategy of phytopathogenic fungi.

Nature communications·2026
Same journal

Hydroxyl-rich nanocavities on perovskite enable nearly barrierless intramolecular hydrogen transfer for nitrate electroreduction to ammonia.

Nature communications·2026
Same journal

Household mobility responses to weather extremes in Kyrgyzstan.

Nature communications·2026
Same journal

Autonomous Motion Vision with Tri-bulk-heterojunctioned Organic Adaptation Transistor.

Nature communications·2026
Same journal

Tissue-adhesive hydrogel optical fiber for peripheral optogenetic neuromodulation.

Nature communications·2026
See all related articles

Related Experiment Video

Updated: Jun 27, 2026

Construction of Modular Hydrogel Sheets for Micropatterned Macro-scaled 3D Cellular Architecture
10:55

Construction of Modular Hydrogel Sheets for Micropatterned Macro-scaled 3D Cellular Architecture

Published on: January 11, 2016

10.2K

Porous hierarchically ordered hydrogels demonstrating structurally dependent mechanical properties.

Elisabeth C Lloyd1, Sujata Dhakal2, Shahrouz Amini3

  • 1Materials Science and Engineering, The Pennsylvania State University, University Park, PA, USA.

Nature Communications
|April 22, 2025
PubMed
Summary
This summary is machine-generated.

Researchers created porous hydrogel fibers mimicking natural tissues using self-assembly. This biomaterial exhibits unique mechanical properties due to its multiscale structure, paving the way for advanced biomaterials.

More Related Videos

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

13.3K
3D Printed Porous Cellulose Nanocomposite Hydrogel Scaffolds
06:36

3D Printed Porous Cellulose Nanocomposite Hydrogel Scaffolds

Published on: April 24, 2019

9.5K

Related Experiment Videos

Last Updated: Jun 27, 2026

Construction of Modular Hydrogel Sheets for Micropatterned Macro-scaled 3D Cellular Architecture
10:55

Construction of Modular Hydrogel Sheets for Micropatterned Macro-scaled 3D Cellular Architecture

Published on: January 11, 2016

10.2K
Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

13.3K
3D Printed Porous Cellulose Nanocomposite Hydrogel Scaffolds
06:36

3D Printed Porous Cellulose Nanocomposite Hydrogel Scaffolds

Published on: April 24, 2019

9.5K

Area of Science:

  • Biomaterials Science
  • Materials Engineering
  • Tissue Engineering

Background:

  • Natural tissues exhibit hierarchical ordering crucial for their properties.
  • Biomaterial synthesis has largely overlooked multiscale structural organization, focusing on molecular approaches.

Purpose of the Study:

  • To develop a bottom-up self-assembly process for creating biomimetic hydrogel fibers.
  • To investigate the impact of multiscale structure on the mechanical properties of synthesized hydrogels.

Main Methods:

  • Utilized a bottom-up self-assembly approach to form physically crosslinked nanostructured micelles.
  • Engineered micrometer-sized, water-rich pores with controlled orientation within hydrogel fibers.
  • Controlled material microstructure and orientation across multiple length scales (nm-μm).

Main Results:

  • Synthesized highly porous hydrogel fibers structurally and mechanically resembling extracellular matrices.
  • Achieved low elastic moduli (<1 kPa), high elasticity (>12x extension), and non-linear elasticity (hyperelasticity).
  • Demonstrated that multiscale structural control directly influences mechanical characteristics.

Conclusions:

  • The bottom-up self-assembly process successfully generates biomimetic hydrogel fibers.
  • The observed mechanical properties are attributed to the interplay between pore structure and polymer chains.
  • Controlling multiscale architecture is key to tailoring biomaterial mechanical performance.