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Updated: May 12, 2025

Assays for Validating Histone Acetyltransferase Inhibitors
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Histone deacetylases and their inhibitors in kidney diseases

Yue Zheng1, Tie-Ning Zhang1, Peng-Hui Hao1

  • 1Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang 110004, China.

Molecular Therapy : the Journal of the American Society of Gene Therapy
|April 23, 2025
PubMed

Insights

Histone deacetylases (HDACs) are key in kidney disease. HDAC inhibitors show therapeutic promise for chronic kidney disease (CKD), acute kidney injury (AKI), and diabetic kidney disease (DKD), but require further research for optimal use.

Area of Science:

  • Nephrology
  • Molecular Biology
  • Pharmacology

Background:

  • Histone deacetylases (HDACs) play a crucial role in kidney disease development and progression.
  • Understanding HDACs is vital for managing various kidney conditions.

Purpose of the Study:

  • To review recent advancements in HDAC research concerning kidney diseases.
  • To explore the therapeutic potential of HDAC inhibitors in kidney disease treatment.

Main Methods:

  • Literature review of studies on HDACs in kidney development and disease.
  • Analysis of HDAC inhibitor mechanisms and therapeutic effects.
  • Evaluation of challenges and future directions for HDAC inhibitor therapy.

Main Results:

  • HDACs are implicated in the pathogenesis of chronic kidney disease (CKD), acute kidney injury (AKI), autosomal dominant polycystic kidney disease (ADPKD), and diabetic kidney disease (DKD).
  • HDAC inhibitors demonstrate protective effects by modulating apoptosis, autophagy, inflammation, and fibrosis.
  • Targeting specific HDAC isoforms offers therapeutic potential for various kidney conditions.

Conclusions:

  • HDAC inhibitors represent a promising therapeutic strategy for kidney diseases.
  • Further research is needed to enhance HDAC inhibitor selectivity, reduce toxicity, and improve pharmacokinetics.
  • This review provides insights for future research and prevention strategies in kidney disease management.

Keywords:
HDAC inhibitorsepigeneticshistone deacetylaseskidney diseases

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